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Perform LD clumping for the SNP study

Whether to search through pre-clumped dataset or even re also-extract and clump directly from the fresh host. Works 1st multivariable MR study of Burgess et al 2015.Per publicity the results is actually residualised for your most other exposures, then unweighted regression are applied. The brand new default multiplicative random outcomes IVW estimate.The standard mistake is actually fixed for under dispersionUse the new mr_ivw_mre() mode to possess prices that don’t proper for less than dispersion. Make sure he or she is centered on the same impact allele as the conclusion dataset. To perform MR the end result away from a great SNP to the an end result and you may publicity must be harmonised to berelative to the exact same allele.

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